The METHYLOMIC project is advancing research to make personalised treatments for Crohn’s Disease (CD) and similar immune-mediated conditions a reality.

By building on previous studies, researchers have identified specific patterns in DNA methylation (a type of genetic marker) that can predict how well a patient will respond to certain biological therapies for CD. These markers, found in blood samples, have already been validated for three approved biological treatments, with prediction accuracy reaching up to 93% using advanced machine learning techniques. 

The GlycanTrigger project proposes a thorough and innovative approach to understand better the health-to-chronic inflammation transition occurring in patients with CD that will be translated into improved disease prediction and prevention.

The GENEGUT project will transform the treatment of ileal CD by developing a first-in-class oral RNA-based therapy, tackling inflammation locally in the intestinal tissue, while avoiding systemic side effects.

EFCCA  is involved in an exciting EU Research Project under the Innovative Medicines Initiative (IMI 2) (Horizon 2020).

The ImmUniverse project main goal is the improved diagnostic and therapeutic options for patients living with ulcerative colitis and atopic dermatitis. New insights into disease severity and progression will enable personalised therapy for each individual patient.

EFCCA is involved in this exciting project that will identify digital endpoints that provide reliable, objective and sensitive evaluation of activities of daily living and Health-related quality of life (HRQoL) in ImmuneMediated Inflammatory Diseases such as IBD as well as other such as Rheumatoid Arthritis and Lupus and which will ultimately have a positive impact on the quality of life of these patients. 

Background

Transitioning through paediatric and into adult care is a critical time for patients and, if not carried out effectively and appropriately, can impact on education, mental health and patient outcomes. It has become clear that this is a major issue for patients, their carers and clinicians and that the transition process within and across Europe urgently needs reform.